Pubblicazione sulla rivista International Journal of Molecular Sciences

Pubblicato il Pubblicato in Uncategorized

E' di ieri la notizia che la prestigiosa rivista Internation Journal of Molecular Science ha appena accettata la pubblicazione dell'articolo "Insights into the Periplasmic Proteins of Acinetobacter baumannii AB5075 and the Impact of Imipenem Exposure: A Proteomic Approach" a firma del Dipartimento di Sanità Pubblica e Malattie Infettive che contribuiamo a supportare da anni.

E' un indissolubile rapporto che si fonda sulle radici della mission e della vision della Fondazione Dani Di Giò - Onlus.

L'identità della Fondazione sarà vicino al team del Dipartimento al Congresso Internazionale ACINETOBACTER 2019 che si terrà a Francoforte dal 4 al 6 settembre.

 

Lasciamo l'abstract in lingua inglese per una prima lettura ed un link in basso per poter scaricare l'intero articolo:

"Carbapenem-resistant Acinetobacter baumannii strains cause life-threatening infections due to the lack of therapeutic options. Although the main mechanisms underlying antibiotic-resistance have been extensively studied, the general response to maintain bacterial viability under antibiotic exposure deserves to be fully investigated. Since the periplasmic space contains several proteins with crucial cellular functions, besides carbapenemases, we decided to study the periplasmic proteome of the multidrug-resistant (MDR) A. baumannii AB5075 strain, grown in the absence and presence of imipenem (IMP). Through the proteomic approach, 65 unique periplasmic proteins common in both growth conditions were identified: eight proteins involved in protein fate, response to oxidative stress, energy metabolism, antibiotic-resistance, were differentially expressed. Among them, ABUW_1746 and ABUW_2363 gene products presented the tetratricopeptide repeat motif, mediating protein-protein interactions. The expression switch of these proteins might determine specific protein interactions to better adapt to changing environmental conditions. ABUW_2868, encoding a heat shock protein likely involved in protection against oxidative stress, was upregulated in IMP-exposed bacteria. Accordingly, the addition of periplasmic proteins from A. baumannii cultured with IMP increased bacterial viability in an antioxidant activity assay. Overall, this study provides the first insights about the composition of the periplasmic proteins of a MDR A. baumannii strain, its biological response to IMP and suggests possible new targets to develop alternative antibiotic drugs."

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